Development of Synthetic Cannabinoids based on Molecular Mechanisms

Together with our partner – National Cancer Institute of Lithuania, we are empirically examining the potential of natural and novel synthetic cannabinoids for targeted cancer treatment. Starting with in vitro experiments, we will examine the bioactivity of a vast range of different cannabinoids identifying the most promising ones and conducting their further evaluation.

The substrate scope will be greatly expanded by including a collection of synthetic cannabinoids possessing unconventional molecular scaffolds and pharmacophores. The vast chemical space available through stereoselective synthesis using starting materials and reaction sequences not previously explored holds a promise of a substantial breakthrough in identifying new therapeutic agents.

These natural and synthetic compounds will also be used to develop pharmaceutical ingredients for treatment and prevention of the Alzheimer’s disease. The project will be conducted in partnership with the Life Sciences Centre of Vilnius University.