Cannabidiol is one of the many cannabinoids found in hemp plant. Even though some articles claim that there is well over 100 of cannabinoids, CBD is one of the best described ones. Decades of research have revealed it’s potential benefits, side effects, uses and even allowed pharmaceutical companies to develop medicinal treatments based on this molecule. So, let’s dive and explore this interesting compound!
What is CBD?
First and foremost, in scientific perspective CBD isolate is a compound found in majority of hemp strains with modest to high percentages, it is a phenolic compound with two ring motifs in the molecule. In it’s purest form – it is a white crystalline material that is usually accompanied by subtle hemp aroma. Aroma naturally comes from hemp plant as most of CBD is sourced from the plant and scent carries over during the extraction and purification procedures. Years of cannabinoid research and development reveal that CBD has plethora of molecular targets throughout the body as it binds to or acts upon many biologically important receptors: the classical endocannabinoid receptors CB1 and CB2, TRPA1, TRPV2, 5-HT1A, PPARy and many more. It is also important to note that CBD should not be mixed with recently introduced CBDV as CBD vs CBDV are two unique compounds.
A natural molecule with medicinal benefits.
Historically, cannabis was used for thousands of years by our ancestors in ceremonial settings, but cannabis as an aid for the sick has been resurrected rather recently in the Western medicine – around 19th century and first FDA approvals have been granted only in 20th century. Curiously, as often happens, Eastern medicine was aware of medicinal benefits much earlier. Aside from management of cancer symptoms’, cannabinoids, in particular CBD, have other pharmaceutical benefits. Only four years ago a formulation based on CBD was approved by FDA to treat seizures, associated with Lennox-Gastaut and Dravet syndromes, it also shows potential for treatment of seizures from tuberous sclerosis complex. Moreover, phase 2 clinical trials for osteoarthritis and arthritis are underway, so there is something to look for. Especially, as side effects such as sleepiness, decreased appetite (which is also investigated as an application in treatment of obesity), diarrhea, vomiting and others are generally comparable to side effects of non-steroidal anti-inflammatory drugs (NSAIDs) which are typically employed in arthritis management.
Latest research and what to look forward to?
As it has been already discussed – research and clinical trials are undergoing currently and that is the most important part after decades of cannabis and cannabinoid negligence and prosecution by authorities. Since the times for cannabinoid research are as good as they have ever been – we can expect more peer-reviewed academic articles with interesting new applications as well as new data from clinical research indicating possible future applications.
Most importantly, every consumer should get the best quality CBD products and all of this starts with trusted bulk ingredient manufacturer supplying raw ingredients to verified brands. This is where we step in with our natural CBD isolate. At Sanobiotec we try to excel in each step – extraction, manufacturing, synthesis, purification and quality control. Years of accumulated expertise allows us to perfect our products by purifying them in most appropriate methods for each and every product we offer, be it (semi) synthetic or natural. This includes, but is not limited to extraction, chromatography, distillation and other techniques. As far as production and quality control goes – we follow each step and carefully inspect our products with GC, LC, NMR and other analytical machines. We do all of this so that our customers get the purest, highest potency and quality products on the market. If you want to join our satisfied clients – be sure to drop us a line or book a call!
Sources
https://en.wikipedia.org/wiki/History_of_medical_cannabis
https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms
https://www.drugs.com/history/epidiolex.html
https://clinicaltrials.gov/ct2/show/NCT03693833
https://clinicaltrials.gov/ct2/show/NCT04611347
https://www.ema.europa.eu/en/medicines/human/EPAR/epidyolex
https://www.nhs.uk/conditions/nsaids/
https://pubmed.ncbi.nlm.nih.gov/22543671/
https://pubmed.ncbi.nlm.nih.gov/21175579/
https://www.jneurosci.org/content/28/24/6231
https://pubs.acs.org/doi/10.1021/cn5000524
https://onlinelibrary.wiley.com/doi/10.1111/adb.12783
This post was brought to you by our inhouse scientist Simonas Balkaitis